RB-associated KRAB zinc finger protein (RB-associated KRAB repressor, hRBaK, zinc finger protein 769, RBAK, ZNF769)

Function: - may repress E2F-dependent transcription - may promote AR-dependent transcription - interacts with AR & RB1 - may also interact with other nuclear hormone receptors such as NR3C1/GR Structure: - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 16 C2H2-type Zn⁺² fingers - contains 1 KRAB domain Compartment: nucleus Expression: - expressed in bone, brain, heart, kidney, liver, lung, pancreas & placenta

General

nuclear protein zinc finger protein

Properties

SIZE: entity length = 714 aa MW = 83 kD COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 8-79 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 interaction with RB1 {171-260} Zn finger C2H2-type SITE: 261-283 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 289-311 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 317-339 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 345-367 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 373-395 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 401-423 EFFECTOR-BOUND: Zn+2 AR interaction {417-714} MOTIF: Zn finger C2H2-type SITE: 429-451 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 457-479 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 485-505 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 511-533 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 539-561 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 567-589 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 595-617 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 623-645 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 651-673 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 679-701 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q9NYW8 PFAM correlations Kegg hsa:5778

References

UniProt :accession Q9NYW8