Ras-specific guanine nucleotide-releasing factor RalGPS2 (RalA exchange factor RalGPS2, Ral GEF with PH domain & SH3-binding motif 2) (RALGPS2)

Function: - guanine nucleotide exchange factor for the small GTPase RalA. - may be involved in cytoskeleton organization - may also be nvolved in the stimulation of transcription (Ras-independent) - interacts with SH3 domain of GRB2 & PLCG1 Structure: - PH domain mediates binding to PIP2 - contains 1 PH domain - contains 1 Ras-GEF domain Compartment: - cytoplasm, cell membrane - associated with membranes through PH domain Alternative splicing: named isoforms=2 Pathology: - defects in RALGPS2 gene may be a cause of Alzheimer disease

General

guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS) phosphoprotein

Properties

SIZE: entity length = 583 aa MW = 65 kD COMPARTMENT: cytoplasm MOTIF: guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain SITE: 49-287 PXXP {324-327} MOTIF: Thr phosphorylation site {T326} Ser phosphorylation site {S329} Ser phosphorylation site {S343} PH domain {457-569}

Database Correlations

UniProt Q86X27 PFAM correlations Kegg hsa:5510

References

UniProt :accession Q86X27