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Ras-specific guanine nucleotide-releasing factor RalGPS1 (RalA exchange factor RalGPS1, Ral GEF with PH domain & SH3-binding motif 1, RALGPS1, KIAA0351, RALGEF2)
Function:
- may be involved in cytoskeletal organization
- may also be involved in the stimulation of transcription (Ras-independent)
- guanine nucleotide exchange factor for small GTPase RALA
- interacts with the SH3 domains of GRB2, NCK1, PLCG1 & SRC
- interacts with RALA
Structure:
- contains 1 PH domain
a) mediates binding to membranes (probable)
b) required for guanine nucleotide exchange of RALA
- contains 1 Ras-GEF domain
Compartment:
- cytoplasm (putative), cell membrane (probable)
- associates with membranes through the PH domain (probable) Alternative
- splicing, named isoforms=6
Expression:
- isoform 2 is expressed in brain, colon, kidney, pancreas, prostate, skeletal muscle, small intestine, testis, thymus & uterus
- isoform 1 is expressed in heart & testis > brain, pancreas, skeletal muscle, small intestine & thymus
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: entity length = 557 aa
MW = 62 kD
COMPARTMENT: cytoplasm
MOTIF: serine-rich region {21-26}
MOTIF: serine residue (SEVERAL)
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 50-289
PXXP {330-333}
PH domain {431-543}
RALA interaction {433-557}
Database Correlations
UniProt Q5JS13
PFAM correlations
Kegg hsa:9649
References
UniProt :accession Q5JS13