RAS-responsive element-binding protein 1 (RREB-1, Raf-responsive zinc finger protein LZ321, RREB1)

Function: 1) transcription factor 2) binds specifically to the distal RAS-responsive element (RRE) in the calcitonin gene promoter & augments the Ras/Raf- mediated transcriptional response 3) role in Ras/Raf-mediated cell differentiation Structure: - contains 4 C2H2-type zinc fingers Compartment: nucleus Expression: - expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas - not found in brain

General

C2H2 type zinc finger protein DNA-binding protein phosphoprotein transcription factor (TF)

Properties

SIZE: MW = 80 kD entity length = 755 aa COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S236} Zn finger C2H2-type SITE: 315-337 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 461-483 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 580-602 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 608-630 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 602209 UniProt Q92766 Pfam PF00096

References

UniProt :accession Q92766