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RAS guanyl-releasing protein 4 (RASGRP4)
Function:
- cation- & diacylglycerol (DAG)-regulated guanine nucleotide exchange factor activating Ras through exchange of bound GDP for GTP
- may function in mast cells differentiation
Structure:
- phorbol-ester/DAG-type Zn+2 finger mediates the binding & the functional activation by DAG
- belongs to the RASGRP family
- contains 1 EF-hand domain
- contains 1 N-terminal Ras-GEF domain
- contains 1 phorbol-ester/DAG-type Zn+2 finger
- contains 1 Ras-GEF domain
Compartment:
- cytoplasm, cell membrane
- recruited to membranes upon activation by DAG
Alternative splicing: named isoforms=4
Expression:
- expressed by mast cells & their progenitors (at protein level)
- specifically expressed in mononuclear leukocytes
- highly expressed in myeloid cells compared to lymphoid cells
- detected in heart, skeletal muscle, spleen, liver, placenta & lung
- not detected in brain
- expressed early during development
- detected in all fetal tissues tested
General
Ca+2 binding protein
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
zinc finger protein
Properties
SIZE: entity length = 673 aa
MW = 75 kD
COMPARTMENT: cytoplasm
MOTIF: guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 49-175
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 201-432
EF hand
SITE: 466-501
Zinc finger
NAME: Zinc finger
SITE: 540-590
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 607320
UniProt Q8TDF6
PFAM correlations
Kegg hsa:1157
References
UniProt :accession Q8TDF6