RAS guanyl-releasing protein 3 (Ca+2 DAG-regulated guanine nucleotide exchange factor 3, guanine nucleotide exchange factor for Rap1)

Function: - guanine nucleotide exchange factor (GEF) for Ras & Rap1 Structure: - contains 2 EF-hand domains - contains 1 N-terminal Ras-GEF domain - contains 1 phorbol-ester/DAG-type zinc finger - contains 1 Ras-GEF domain

General

Ca+2 binding protein guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS) zinc finger protein

Properties

SIZE: MW = 78 kD entity length = 690 aa MOTIF: guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain SITE: 3-125 guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain SITE: 152-383 EF hand SITE: 420-455 EF hand SITE: 449-484 Zinc finger NAME: Zinc finger SITE: 494-544 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q8IV61 PFAM correlations

References

UniProt :accession Q8IV61