Contents

Search

ras guanine nucleotide releasing factor 1; Ras-specific guanine nucleotide-releasing factor 1; Ras-GRF1; guanine nucleotide-releasing factor 1; Ras-specific nucleotide exchange factor CDC25 (RASGRF1, CDC25, GNRP, GRF1)

Protein distinct from ras-GAP. Function: - promotes the exchange of Ras-bound GDP by GTP - catalyzes release of GTP from p21H-ras & p21N-ras. - ubiquitinated (putative) - homooligomer & heterooligomer with RASGRF2 - interacts with USP8, thereby regulating its stability (putative) Structure: - may be related to CDC25 protein of Saccharomyces cerevisiae - the DH (DBL-homology) domain mediates interaction with RASGRF2 - contains 1 DH (DBL-homology) domain - contains 1 IQ domain - contains 1 N-terminal Ras-GEF domain - contains 2 PH domains - contains 1 Ras-GEF domain Alternative splicing: named isoforms=2

Interactions

molecular events

Related

M-phase inducer phosphatase or CDC25

General

guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS) phosphoprotein

Properties

SIZE: MW = 145 kD entity length = 1275 aa MOTIF: PH domain {22-129} IQ motif {204-229} Dbl homology domain {240-426} PH domain {467-584} guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain SITE: 644-762 guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain SITE: 1040-1272

Database Correlations

OMIM 606600 UniProt Q13972 PFAM correlations Entrez Gene 5923 Kegg hsa:5923

References

  1. Wolfman A, Macara IG. A cytosolic protein catalyzes the release of GDP from p21ras. Science. 1990 Apr 6;248(4951):67-9. PMID: 2181667
  2. Marx Science 251:484 1992
  3. Shou C, Farnsworth CL, Neel BG, Feig LA. Molecular cloning of cDNAs encoding a guanine-nucleotide- releasing factor for Ras p21. Nature. 1992 Jul 23;358(6384):351-4. PMID: 1379346
  4. Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science. 1993 May 28;260(5112):1338-43. PMID: 8493579
  5. Boguski MS & McCormick F Proteins regulating Ras and its relative. Nature 366:643 1993 PMID: 8259209
  6. UniProt :accession Q13972
  7. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/RASGRF1ID43453ch15q25.html