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rap guanine nucleotide exchange factor 1; guanine nucleotide-releasing factor 2; C3G protein; CRK SH3-binding GNRP (RAPGEF1 GRF2)
Function:
- guanine nucleotide-releasing protein
- binds to SH3 domain of CRK & GRB2/ASH
- transduces signals from CRK to activate RAS
- interacts with CRK via its SH3-binding sites
Structure:
- contains 1 N-terminal Ras-GEF domain
- contains 1 Ras-GEF domain
Alternative splicing: named isoforms=2
Expression:
- ubiquitously expressed in adult & fetus
- expression is high in adult skeletal muscle & placenta & in fetal brain & heart
- low levels of expression in adult & fetal liver
Interactions
molecular events
Related
ras signal transduction
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
phosphoprotein
Properties
SIZE: entity length = 1077 aa
MW = 121 kD
MOTIF: peptide motif {281-292}
Ser phosphorylation site {S360}
peptide motif {451-462}
peptide motif {538-549}
peptide motif {606-617}
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 688-810
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 840-1064
MOTIF: serine-rich region {963-966}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 600303
UniProt Q13905
PFAM correlations
Entrez Gene 2889
Kegg hsa:2889
References
- Pawson T.
Protein modules and signalling networks.
Nature. 1995 Feb 16;373(6515):573-80. Review.
PMID: 7531822
- Clark EA & Brugge JS
Integrins and signal transduction pathways: the road taken.
Science 268:233 1995
PMID: 7716514
- UniProt :accession Q13905
Component-of
molecular complex