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Ras-GEF domain-containing family member 1A (RASGEF1A)
Function:
- guanine nucleotide exchange factor (GEF) for KRAS, HRAS, & NRAS (in vitro)
- role in cell migration
Structure:
- contains 1 N-terminal Ras-GEF domain
- contains 1 Ras-GEF domain
Alternative splicing: named isoforms=2
Expression:
- detected in brain & spinal cord
Pathology:
- highly expressed in a number of intrahepatic cholangiocarcinoma tissue biopsies
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: entity length = 481 aa
MW = 55 kD
MOTIF: guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 41-170
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 214-461
Database Correlations
UniProt Q8N9B8
PFAM correlations
References
UniProt :accession Q8N9B8