Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2, PDZ-GEF2, RA-GEF-2, RAPGEF6, PDZGEF2)

Function: 1) guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A & M-Ras GTPases 2) does not interact with cAMP 3) interacts with the second PDZ domain of human PTP1e Compartment: - cytoplasm - upon binding to M-Ras, translocates to plasma membrane Alternative splicing: named isoforms=3 Expression: - expressed in brain, heart, liver, lung, placenta > skeletal muscle, kidney, pancreas (isoform 3)

General

guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS) phosphoprotein

Properties

SIZE: MW = 179 kD entity length = 1601 aa MOTIF: guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain SITE: 412-526 PDZ domain NAME: PDZ domain SITE: 530-615 RAS-ASSOCIATING {749-835} guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain SITE: 860-1088 serine-rich region {1229-1440} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S1494}

Database Correlations

UniProt Q8TEU7 PFAM correlations

References

UniProt :accession Q8TEU7