Search
Rap guanine nucleotide exchange factor 5 (guanine nucleotide exchange factor for Rap1, related to Epac, Repac, M-Ras-regulated Rap GEF, MR-GEF, RAPGEF5, GFR, KIAA0277, MRGEF)
Function:
- guanine nucleotide exchange factor for RAP1A, RAP2A & MRAS/M-Ras-GTP
- its association with MRAS inhibits Rap1 activation
Structure:
- contains 1 N-terminal Ras-GEF domain
- contains 1 Ras-GEF domain
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression: widely expressed with highest levels in brain
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: MW = 68 kD
entity length = 580 aa
COMPARTMENT: cell nucleus
MOTIF: guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 68-201
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 345-579
Database Correlations
UniProt Q92565
PFAM correlations
References
UniProt :accession Q92565