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Rap guanine nucleotide exchange factor 2 (PDZ domain-containing guanine nucleotide exchange factor 1, neural RAP guanine nucleotide exchange protein, nRap GEP, PDZ-GEF1, RA-GEF, RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1)
Function:
1) guanine nucleotide exchange factor (GEF) for Rap1A, Rap1B, Rap2B GTPases
2) does NOT interact with cAMP or cGMP
3) interacts with MAGI2
Compartment:
- cell membrane
- associated with synaptic plasma membrane (putative)
Expression: expressed in brain > heart, kidney, lung, placenta
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
phosphoprotein
Properties
SIZE: MW = 167 kD
entity length = 1499 aa
MOTIF: guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 267-380
PDZ domain
NAME: PDZ domain
SITE: 385-470
RAS-ASSOCIATING {606-692}
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 717-944
serine-rich region {1108-1166}
MOTIF: serine residue (SEVERAL)
Database Correlations
UniProt Q9Y4G8
PFAM correlations
References
UniProt :accession Q8TEU7