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Rappaport Luebering pathway

Pathway from 1,3-diphosphoglycerate (1,3-DPG) to 3-phospho- glycerate (3-PG) through 2,3-diphosphoglycerate (2,3-DPG), presumably to generate 2,3-DPG for regulation of hemoglobin oxygen affinity in erythrocytes. The pathway, a detour off the pathway of glycolysis, comes at a cost, sacrificing production of ATP in the conversion of 1,3-DPG to 3-PG. 2,3-DPG mutase 2,3-DPG phosphatase 1,3-DPG --------------> 2,3-DPG -------------------> 3-PG

Related

1,3-diphosphoglycerate 2,3-di(bis)phosphoglycerate mutase/phosphatase 2,3-diphosphoglycerate (2,3-DPG); 2,3-bisphosphoglycerate (2,3-BPG) 3-phosphoglycerate

General

molecular pathway

References

  1. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 663
  2. Stryer Biochemistry WH Freeman & Co, New York, 1988 pg 157