Contents

Search

rap1A proto-oncogene protein, Krev-1 proto-oncogene protein, small GTP-binding protein 21A (smg p21A) or rap1A6 proto-oncogene protein

Forms high affinity complex with ras-GAP. Function: - induces morphological reversion of a cell line transformed by a Ras oncogene - counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs & RAF in a competitive manner - Rap1A may function by competing with ras proteins for interaction with their effectors (i.e. raf1, etc.) - in its GTP-bound form, interacts with PLCE1 & RADIL - interacts with SGSM1, SGSM2 & SGSM3 - activated by guanine nucleotide-exchange factors EPAC & EPAC2 (cAMP-dependent manner) - activated by MRGEF Structure: belongs to the small GTPase superfamily, Ras family Compartment: cell membrane; lipid-anchor Notes: - the synonym krev1 derives from the ability of rap1A to reverse cellular transformation induced by K-ras & Smgp21

Interactions

molecular events

Related

rap1A proto-oncogene or krev1 proto-oncogene

General

ras-associated protein (rap)

Properties

SIZE: entity length = 184 aa MW = 21 kD COMPARTMENT: plasma membrane MOTIF: GTP-binding site SITE: 10-17 Effector region (Probable) {32-40} GTP-binding site SITE: 57-61 GTP-binding site SITE: 116-119 CaaX motif SITE: C-TERMINUS QUALITIES: AAX-TRUNCATED CARBOXYMETHYLATED EFFECTOR-BOUND: geranylgeranyl{C20} BOUND-VIA: cysteine residue

Database Correlations

OMIM 179520 UniProt P62834 Pfam PF00071 Entrez Gene 5906 Kegg hsa:5906

References

  1. Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: 1988147
  2. Seizinger BR & Breakefield XO The role of 'tumor suppressor' genes in neural tumors TINS 13:3 1990 PMID: 1688673
  3. Boguski MS & McCormick F Proteins regulating Ras and its relative. Nature 366:643 1993 PMID: 8259209
  4. UniProt :accession P62834
  5. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/RAP1AID272.html

Component-of

molecular complex