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GTP-binding nuclear protein Ran; GTPase Ran; Ras-related nuclear protein; Ras-like protein TC4; androgen receptor-associated protein 24; spi1 protein (RAN, ARA24, OK/SW-cl81)

Function: - nucleocytoplasmic transport a) import of proteins into nucleus b) export of RNA from nucleus - chromatin condensation - cell cycle control - enhances androgen receptor (AR) mediated transactivation; a) interacts with AR N-terminal poly-Gln region b) interaction with AR is inversely correlated with the poly-Gln length - forms a complex with CHC1 - part of a complex consisting of RANBP9, Ran, DYRK1B & COPS5 - found in a nuclear export complex with RANBP3 & XPO1 - component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN & XPO1 - found in a trimeric export complex with SNUPN, Ran & XPO1 - interacts with RANBP10 Structure: - monomer - N-terminus is blocked - belongs to the small GTPase superfamily, Ran family Compartment: - nucleus,cytoplasm. melanosome - becomes dispersed throughout the cytoplasm during mitosis - in melanosome fractions from stage 1 to stage 4 Expression: expressed in a variety of tissues Pathology: - in HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) & XPO1 - found in a complex with HTLV-1 Rex, RANBP3 & XPO1

General

nuclear protein ran subfamily protein

Properties

SIZE: entity length = 216 aa MW = 24 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl GTP-binding site SITE: 17-24 GTP-binding site SITE: 65-69 GTP-binding site SITE: 122-125 Tyr phosphorylation site {Y147} Tyr phosphorylation site {Y155}

Database Correlations

OMIM 601179 UniProt P62826 Pfam PF00071 Entrez Gene 5901 Kegg hsa:5901

References

  1. Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: 1592203
  2. Scheffzek K, Klebe C, Fritz-Wolf K, Kabsch W, Wittinghofer A. Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form. Nature. 1995 Mar 23;374(6520):378-81. PMID: 7885480 (crystal structure)
  3. UniProt :accession P17080

Component-of

U snRNA export complex