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Ran guanine nucleotide release factor (RanGNRF, Ran-binding protein MOG1, RANGRF, MOG1, RANGNRF, HSPC165, HSPC236, MDS5)
Function:
- may regulate the intracellular trafficking of RAN
- in cardiac cells seems to regulate the cell surface localization of SCN5A
Structure:
- monomer (putative)
- interacts with RAN, RAN-GTP & RAN-GDP
- forms a complex with RAN-GTP & RANBP1 (putative)
- interacts with the cytoplasmic loop 2 of SCN5A belongs to the MOG1 family
Compartment:
- nucleus, cytoplasm
- shuttles between the nucleus & cytoplasm
Alternative splicing: named isoforms=4
Expression: isoforms 1 & 2 are ubiquitously expressed
General
nuclear protein
Properties
SIZE: entity length = 186 aa
MW = 20 kD
COMPARTMENT: cytoplasm
cell nucleus
Database Correlations
OMIM 607954
UniProt Q9HD47
Pfam PF04603
Kegg hsa:2909
References
UniProt :accession Q9HD47