Ran-binding protein M; Ran-binding protein 9; RanBP9; BPM-L; BPM90; RanBPM; RanBP7 (RANBP9, RANBPM)

One of two Ran-binding protein 9. Importin-9 is the other. Function: - may act as an adapter protein to couple membrane receptors to intracellular signaling pathways - may be involved in signaling of ITGB2/LFA-1 & other integrins - enhances HGF-MET signaling by recruiting Sos & activating the Ras pathway - enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1 - does not affect estrogen-induced transactivation - stabilizes TP73 isoform alpha, probably by inhibiting its ubiquitination, & increases its proapoptotic activity - inhibits kinase activity of DYRK1A & DYRK1B - inhibits FMR1 binding to RNA - phosphorylated upon DNA damage, probably by ATM or ATR - phosphorylated in response to stress - can be phosphorylated by the cleaved p110 form of CDC2L1 (p110C) - ubiquitinated - polyubiquitination targets the protein for rapid degradation - can be deubiquitinated by USP11 - interacts with NGFR & DDX4 (putative) - interacts with GTP-bound Ran, AR, CDC2L1/p110C, CALB1, S100A7, USP11, MKLN1, SOS1 or SOS2, C20orf11, & FMR1 - interacts with the Dyrk kinases HIPK2, DYRK1A, & DYRK1B - interacts with TP73 isoform alpha - does not interact with TP53 - interacts with the HGF receptor MET & the integrins ITGB1 & ITGB2 - does not interact with ITGAL - part of a complex consisting of RANBP9, MKLN1 & C20ORF11 - part of a complex consisting of RANBP9, RAN, DYRK1B & COPS5 - directly interacts with RANBP10 Structure: - the SPRY domain mediates the interaction with MET, AR, & CDC2L1 - belongs to the RANBP9/10 family - contains 1 B30.2/SPRY domain - contains 1 CTLH domain - contains 1 LisH domain Compartment: - cytoplasm, nucleus - predominantly cytoplasmic - phosphorylated form is associated with the plasma membrane Alternative splicing: named isoforms=2 Expression: - ubiquitously expressed - highest expession in testes, placenta, heart, & muscle - lowest expression in lung - within the brain, expressed predominantly by neurons in - gray matter of cerebral corte - cerebellar granular layer - Purkinje cells

General

cytoskeletal protein phosphoprotein

Properties

SIZE: entity length = 729 aa MW = 78 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: proline-rich region SITE: 5-10 MOTIF: proline residue (SEVERAL) glutamine-rich region {11-18} MOTIF: glutamine residue (SEVERAL) proline-rich region SITE: 21-24 MOTIF: proline residue (SEVERAL) alanine-rich region {25-131} MOTIF: alanine residue (SEVERAL) alanine-rich region {62-66} MOTIF: alanine residue (SEVERAL) proline-rich region SITE: 71-77 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 82-92 MOTIF: proline residue (SEVERAL) B30.2/SPRY {147-334} LisH {365-397} CALB1 interaction {401-407} CTLH {403-460} Ser phosphorylation site {S603} FMR1 interaction {615-729}

Database Correlations

OMIM 603854 UniProt Q96S59 PFAM correlations Entrez Gene 10048 Kegg hsa:10048

References

UniProt :accession Q96S59