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Ran-specific GTPase-activating protein; Ran-binding protein 1; RanBP1 (RANBP1)
Function:
- inhibits GTP exchange on Ran
- forms a Ran-GTP-RANBP1 trimeric complex
- increases GTP hydrolysis induced by GTPase activating protein RANGAP1
- may play a role in control progression through the cell cycle by regulating transport of protein & nucleic acids across the nuclear membrane
Structure:
- belongs to the RANBP1 family
- contains 1 RanBD1 domain
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 201 aa
MW = 23 kD
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Thr phosphorylation site {T7}
Thr phosphorylation site {T13}
Ser phosphorylation site {S14}
Thr phosphorylation site {T15}
Thr phosphorylation site {T18}
Ser phosphorylation site {S21}
Ran binding domain type 1 {26-164}
MOTIF: Ser phosphorylation site {S60}
Database Correlations
OMIM 601180
UniProt P43487
Pfam PF00638
Entrez Gene 5902
Kegg hsa:5902
References
UniProt :accession P43487