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Ranson criteria

Ranson criteria provides prognostic information for patients with pancreatitis. Increased morbidity & mortality are associated with the following criteria: Upon admission to hospital: 1) age > 55 years (> 70 for gallstone pancreatitis) 2) WBC > 16,000/mm3 (> 18,000 for gallstone pancreatitis) 3) glucose > 200 mg/dL (> 220 for gallstone pancreatitis) 4) serum LDH > 350 IU/L (> 400 for gallstone pancreatitis) [for reference interval of 90-280 IU/L] 5) AST > 250 IU/L After 48 hours: 1) hematocrit* drop of > 10% 2) rise in serum urea nitrogen* > 5 mg/dL (> 2 for gallstone pancreatitis) 3) arterial pO2 < 60 mm Hg (not a criterium for gallstone pancreatitis) 4) base deficit > 4 meq/L (> 5 meq/L for gallstone pancreatitis) 5) serum Ca+2 < 8.0 mg/dL 6) estimated fluid sequestration > 6 L (> 4 L for gallstone pancreatitis) * see notes Notes: - serial serum urea nitrogen provides the most reliable routine laboratory test to predict mortality [4] - changes in blood hemoglobin do not correlate with disease severity [4]

Related

acute pancreatitis modified Glasgow criteria

General

criteria

References

  1. Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 361
  2. Ranson et al Sur Gynecol Obstet 139:69 1974
  3. Ranson Am J Gastroenterol 77:633 1982
  4. Medical Knowledge Self Assessment Program (MKSAP) 16 American College of Physicians, Philadelphia 2012