Ral guanine nucleotide dissociation stimulator-like 2; RalGDS-like 2; RalGDS-like factor; Ras-associated protein RAB2L (RGL2, RAB2L)

Function: - probable guanine nucleotide exchange factor - effector of Ras &/or rap - associates with the GTP-bound form of rap 1A & H-Ras in vitro (putative) Structure: - contains 1 N-terminal Ras-GEF domain - contains 1 Ras-associating domain - contains 1 Ras-GEF domain

General

guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS) phosphoprotein

Properties

SIZE: entity length = 777 aa MW = 84 kD MOTIF: Ser phosphorylation site {S13} guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain SITE: 88-212 guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain SITE: 243-513 Ser phosphorylation site {S617} Ras-associating {648-735}

Database Correlations

OMIM 602306 UniProt O15211 PFAM correlations Entrez Gene 5863 Kegg hsa:5863

References

UniProt :accession O15211