Ral guanine nucleotide dissociation stimulator-like 1; RalGDS-like 1 (RGL1, KIAA0959, RGL)

Function: - probable guanine nucleotide exchange factor - interacts with Ras (putative) Structure: - contains 1 N-terminal Ras-GEF domain - contains 1 Ras-associating domain - contains 1 Ras-GEF domain Alternative splicing: named isoforms=2 Expression: - expressed in a wide variety of tissues - high expression in heart, brain, kidney, spleen & testis

General

guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS) phosphoprotein

Properties

SIZE: entity length = 768 aa MW = 87 kD MOTIF: guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain SITE: 65-196 guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain SITE: 232-501 Ser phosphorylation site {S520} serine-rich region {541-613} MOTIF: serine residue (SEVERAL) Ras-associating {648-735} MOTIF: Thr phosphorylation site {T670}

Database Correlations

OMIM 605667 UniProt Q9NZL6 PFAM correlations Entrez Gene 23179 Kegg hsa:23179

References

UniProt :accession Q9NZL6