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ral guanine nucleotide exchange factor (ral-GEF, RALGDS)
Function:
- stimulates the dissociation of GDP from the Ras-related RalA & RalB GTPases, allowing GTP binding & activation of the GTPases
- interacts & acts as an effector molecule for R-Ras, H-Ras, K-Ras, & Rap
- interacts with RIT1 & RIT2 (putative)
Structure:
- contains 1 N-terminal Ras-GEF domain contains 1 Ras-associating domain, interacts with Ras contains 1 Ras-GEF domain
Specific
Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3, RGL3)
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: entity length = 914 aa
MW = 101 kD
MOTIF: guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 112-249
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 386-648
MOTIF: Tyr phosphorylation site {Y586}
serine-rich region {714-717}
MOTIF: serine residue (SEVERAL)
serine-rich region {753-765}
MOTIF: serine residue (SEVERAL)
Ras-associating {798-885}
MOTIF: glutamate-rich region {839-844}
MOTIF: glutamate residue (SEVERAL)
Database Correlations
OMIM 601619
UniProt Q12967
PFAM correlations
References
- Boguski MS & McCormick F
Proteins regulating Ras and its relative.
Nature 366:643 1993
PMID: 8259209
- UniProt :accession Q12967