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Death domain-containing protein CRADD; Caspase & RIP adapter with death domain; RIP-associated protein with a death domain (CRADD, RAIDD)
Function:
- apoptotic adaptor molecule specific for caspase-2 & FASL/TNF receptor-interacting protein RIP
- in the presence of RIP & TRADD, CRADD recruites caspase-2 to the TNFR-1 signalling complex
- interacts with LRDD
Structure:
- contains 1 death domain involved in binding of RIP
- the CARD domain mediates the interaction with caspase-2
- contains 1 CARD domain
Expression:
- constitutively expressed in most tissues
- high expression in adult heart, testis, liver, skeletal muscle, fetal liver & kidney
Interactions
molecular events
General
pro apoptotic protein
Properties
SIZE: entity length = 199 aa
MW = 23 kD
MOTIF: CARD domain {1-91}
death domain
NAME: death domain
SITE: 116-188
Database Correlations
OMIM 603454
UniProt P78560
PFAM correlations
Entrez Gene 8738
Kegg hsa:8738
References
- Duan H & Dixit VM
RAIDD is a new 'death' adaptor molecule.
Nature 385:86-89, 1997
PMID: 8985253
- Entrez Gene :accession 8738
- UniProt :accession P78560
Component-of
molecular complex