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radixin (RDX)
Function:
- probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane
- phosphorylated by tyrosine-protein kinases (putative)
- binds SLC9A3R1. interacts with NHERF1, NHERF2, LAYN, MME/NEP & ICAM2 (putative)
Structure:
- the N-terminal domain interacts with the C-terminal domain of LAYN
- an interdomain interaction between its N-terminal & C-terminal domains inhibits its ablilty to bind LAYN
- in the presence of acidic phospholipids, the interdomain interaction is inhibited & this enhances binding to LAYN (putative)
- contains 1 FERM domain
Compartment:
- cell membrane
- peripheral membrane protein cytoplasmic side
- cytoplasm, cytoskeleton
- highly concentrated in the undercoat of the cell-to-cell adherens junction in interphase & the cleavage furrow in the mitotic phase
Pathology:
- defects in RDX are the cause of autosomal recessive non-syndromic sensorineural deafness type 24
General
cytoskeletal protein
Properties
SIZE: entity length = 583 aa
MW = 69 kD
COMPARTMENT: cytoplasm
MOTIF: FERM domain
NAME: FERM domain
SITE: 5-295
MOTIF: binding site
SITE: 60-63
FOR-BINDING-OF: phosphatidylinositol
Tyr phosphorylation site {Y270}
binding site
SITE: 278-278
FOR-BINDING-OF: phosphatidylinositol
glutamate-rich region {311-522}
MOTIF: glutamate residue (SEVERAL)
proline-rich region
SITE: 470-477
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM correlations
MORBIDMAP 179410
UniProt P35241
PFAM correlations
Entrez Gene 5962
Kegg hsa:5962
References
- UniProt :accession P35241
- Stossel TP.
On the crawling of animal cells.
Science. 1993 May 21;260(5111):1086-94. Review.
PMID: 8493552