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rab5 proto-oncogene protein
Function:
1) plasma membrane-early endosome transport
2) early endosome fusion & mobility
Related
rab-5 proto-oncogene
Specific
rab5a proto-oncogene protein; Ras-related protein Rab-5A (RAB5A, RAB5)
rab5b proto-oncogene protein; Ras-related protein Rab-5B (RAB5B)
rab5c proto-oncogene protein; Ras-related protein Rab-5C; RAB5L; L1880 (RAB5C, RABL)
General
rab subfamily protein
Properties
SIZE: MW = 20-29 kD
COMPARTMENT: endosome
endosome
secretory vesicle
plasma membrane
MOTIF: active site
P-loop
FOR-BINDING-OF: guanosine triphosphate
guanosine diphosphate
cysteine residue {C-TERMINAL}
MODIFICATION: prenyl
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: prenyl
BOUND-VIA: cysteine residue
References
- Seabra MC et al
Rab GTPases, intracellular traffic and disease
Trends in Molecular Medicine 8:23, 2002
PMID: 11796263