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rab3A proto-oncogene protein; small GTP-binding protein 25A; Ras-related protein Rab-3A (RAB3A, smg p25A)

Function: - role in exocytosis via regulating a late step in synaptic vesicle fusion - role in neurotransmitter release via regulating membrane flow in the nerve terminal - regulation of secretion at brain synapses (neurotransmitter release) & from endocrine & exocrine cells - heterodimer with RIMS2 - part of a ternary complex involving PCLO & EPAC2 - interacts with RPH3A - interacts with the exocyst complex through SEC15 - binds SYTL4, RIMS1 & RIMS2 - interacts with RAB3IP - interacts with SGSM1 & SGSM3 Structure: belongs to the small GTPase superfamily, Rab family Compartment: - cell membrane; lipid-anchor; cytoplasmic side (putative) Expression: specifically expressed in brain

Interactions

molecular events

Related

rab-3a proto-oncogene

General

rab3 proto-oncogene protein

Properties

SIZE: entity length = 220 aa MW = 25 kD COMPARTMENT: cytoplasm synaptic vesicle CELL-REGION: axon terminal CELL: neuron WITHIN: brain plasma membrane secretory granule MOTIF: GTP-binding site SITE: 29-36 Ser phosphorylation site {S37} Effector region {51-59} GTP-binding site SITE: 77-81 GTP-binding site SITE: 135-138 Ser phosphorylation site {S188} cysteine residue {C218} MODIFICATION: geranylgeranyl{C20} cysteine residue {C220} MODIFICATION: geranylgeranyl{C20}

Database Correlations

OMIM 179490 UniProt P20336 Pfam PF00071 Entrez Gene 5864 Kegg hsa:5864

References

  1. Matsui Y et al Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP- binding protein. Mol Cell Biol 1990 Aug;10(8):4116-22 PMID: 2115118
  2. Mizoguchi A et al Localization and subcellular distribution of smg p25A, a ras p21-like GTP-binding protein, in rat brain. J Biol Chem 1990 Jul 15;265(20):11872-9 PMID: 2114404
  3. OMIM :accession 179490
  4. Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: 1592203
  5. Boguski MS & McCormick F Proteins regulating Ras and its relative. Nature 366:643 1993 PMID: 8259209
  6. Seabra MC et al Rab GTPases, intracellular traffic and disease Trends in Molecular Medicine 8:23, 2002 PMID: 11796263
  7. Entrez Gene :accession 5864
  8. UniProt :accession P20336

Component-of

molecular complex