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quinolinate phosphoribosyltransferase [decarboxylating] (nicotinate-nucleotide pyrophosphorylase [carboxylating])
Function:
- cofactor biosynthesis; NAD+ biosynthesis
- kynurenine pathway, tryptophan to nicotinate-ribonucleotide, 7th (last) step
- nicotinate ribonucleotide from pyridine-2,3-dicarboxylate
nicotinate D-ribonucleotide + diphosphate + CO2
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
Structure: belongs to the nadC/modD family
Interactions
molecular events
Related
kynurenine pathway
General
allosteric enzyme
oligomerizing protein
pentosyltransferase
Properties
CONFIGURATION: pentamer
SIZE: MW = 170 kD
STATE: active state
MOTIF: active site
allosteric site
Mg+2-binding site
EFFECTOR-BOUND: Mg+2
MISC-INFO: Kd [Mg+2] 1 MM
INHIBITOR = PYROPHOSPHATE
Database Correlations
OMIM 606248
UniProt Q15274
PFAM correlations
Kegg hsa:2347
ENZYME 2.4.2.19
References
UniProt :accession Q15274