quaking protein (Hqk, QKI, HKQ)

Function: 1) RNA-binding protein 2) plays a central role in myelinization 3) binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence 4) regulates pre-mRNA splicing, mRNA export, mRNA stability & protein translation 5) protects & promotes stability of mRNAs such as MBP & CDKN1B to promote oligodendrocyte differentiation 6) mRNA transport - regulates nuclear export of MBP mRNA 7) regulates mRNA splicing of MAG pre-mRNA 8) translational repressor 9) methylated by PRMT1 10) tyrosine phosphorylated at its C-terminus, probably by FYN - phosphorylation leads to decreased mRNA-binding affinity 11) contains 1 KH domain Structure: - homodimer, does not require RNA to homodimerize - forms heterodimer with BICC1 Compartment: nucleus, cytoplasm Alternative splicing: named isoforms=8 Expression: expressed in the frontal cortex of brain Pathology: 1) plays a role in genetic susceptibility to schizophrenia (putative) 2) deletion of the QKI gene may play a role in astrocytomas

General

nuclear protein phosphoprotein RNA-binding protein

Properties

SIZE: MW = 38 kD entity length = 341 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: KH domain SITE: 87-153 FOR-BINDING-OF: ribonucleic acid phosphorylation site SH3-binding site NAME: SH3-binding site SITE: 276-279 nuclear translocation signal {324-330}

Database Correlations

UniProt Q96PU8 Pfam PF00013

References

UniProt :accession Q96PU8