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QACQG
Variation of conserved pentapeptide motif at the active site of the ICE family of cysteine proteases present in MACH/FLICE.
General
active site
Properties
MOTIF: cysteine residue
References
- Boldin MP, Goncharov TM, Goltsev YV, Wallach D.
Involvement of MACH, a novel MORT1/FADD-interacting protease,
in Fas/APO-1- and TNF receptor-induced cell death.
Cell. 1996 Jun 14;85(6):803-15.
PMID: 8681376
- Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A,
Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M,
Krammer PH, Peter ME, Dixit VM.
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is
recruited to the CD95 (Fas/APO-1) death--inducing signaling
complex.
Cell. 1996 Jun 14;85(6):817-27.
PMID: 8681377