Search
cadherin-3; placental cadherin; P-cadherin (CDH3, CDHP)
Function:
- cadherin
- interacts with CDCP1
Structure: contains 5 cadherin domains
Compartment: cell membrane
Alternative splicing: named isoforms=2
Expression:
- expressed in some normal epithelial tissues & in some carcinoma cell lines
Pathology:
- defects in CDH3 are the cause of
a) hypotrichosis with juvenile macular dystrophy
b) ectodermal dysplasia with ectrodactyly & macular dystrophy
General
cadherin
glycoprotein
Properties
SIZE: entity length = 829 aa
MW = 91 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-24}
cadherin domain {108-215}
MOTIF: N-glycosylation site {N200}
cadherin domain {216-328}
cadherin domain {329-440}
cadherin domain {441-546}
cadherin domain {547-650}
MOTIF: N-glycosylation site {N566}
transmembrane domain {655-677}
serine-rich region {785-800}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM correlations
MORBIDMAP 114021
UniProt P22223
PFAM correlations
Entrez Gene 1001
Kegg hsa:1001
References
- UniProt :accession P22223
- Mutations of the CDH3 gene
Retina International's Scientific newsletter
http://www.retina-international.com/sci-news/cdh3mut.htm
GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CDH3
- Takeichi M.
Cadherin cell adhesion receptors as a morphogenetic regulator.
Science. 1991 Mar 22;251(5000):1451-5. Review.
PMID: 2006419
- Walsh FS et al
N-cadherin gene maps to human chromosome 18 and is not linked
to the E-cadherin gene.
J Neurochem. 1990 Sep;55(3):805-12.
PMID: 2384753