pyridoxal kinase, pyridoxine kinase (PDXK, pyridoxamine kinase)

Function: - synthesis of pyridoxal-5-phosphate from vitamin B6 ATP + pyridoxal -> ADP + pyridoxal-5-phsophate Cofactor: - divalent cations - Zn⁺² is more efficient than Mg⁺² Optimum pH is 5.5-6.0 Structure: - homodimer (probable) - belongs to the pyridoxine kinase family Compartment: cytoplasm Alternative splicing: named isoforms=3 Expression: - ubiquitous - isoform 3 is detected in adult testis & spermatozoa

Properties

SIZE: entity length = 312 aa MW = 35 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: 1-1 EFFECTOR-BOUND: acetyl binding site SITE: 12-12 FOR-BINDING-OF: Substrate binding site SITE: 47-47 FOR-BINDING-OF: Substrate binding site SITE: 127-127 FOR-BINDING-OF: Substrate ATP-binding site NAME: ATP-binding site SITE: 186-187 ATP-binding site NAME: ATP-binding site SITE: 223-234 binding site SITE: 235-235 FOR-BINDING-OF: Substrate

Database Correlations

OMIM 179020 UniProt O00764 Pfam PF00294 Kegg hsa:8566 ENZYME 2.7.1.35

References

UniProt :accession O00764