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pygopus homolog 2 (PYGO2)
Function:
- role in signal transduction through the Wnt pathway
- binds to BCL9 via the PHD-type Zn+2 finger motif, & becomes part of the nuclear beta-catenin/TCF complex
Structure: contains 1 PHD-type Zn+2 finger
Compartment: nucleus (probable)
General
phosphoprotein
pygopus homolog
zinc finger protein
Properties
SIZE: entity length = 406 aa
MW = 41 kD
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
proline-rich region
SITE: 6-329
MOTIF: proline residue (SEVERAL)
nuclear translocation signal {41-47}
Ser phosphorylation site {S97}
Thr phosphorylation site {T302}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 327-385
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 606903
UniProt Q9BRQ0
Pfam PF00628
Entrez Gene 90780
Kegg hsa:90780
References
UniProt :accession Q9BRQ0