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Pumilio domain-containing protein KIAA0020 (HBV X-transactivated gene 5 protein, minor histocompatibility antigen HA-8, HLA-HA8, KIAA0020, XTP5)
Structure:
- contains 1 PUM-HD domain
- contains 6 pumilio repeats
- HA-8 region can be cleaved & exposed at cell surface where it plays a role as a minor histocompatibility HLA-A*0201- restricted antigen
Compartment: nucleus, nucleolus
Expression: widely expressed
Polymorphism:
- alleles of HA-8: HA-8R, HA-8P, HA-8PL, of which only HA-8R leads to specific cytotoxic Tlymphocyte (CTL) recognition
- lack of CTL recognition of cells expressing HA-8P may be due to impaired transport associated with antigen processing
General
nuclear protein
Properties
SIZE: MW = 74 kD
entity length = 648 aa
COMPARTMENT: cell nucleus
MOTIF: PUM-HD {143-510}
MOTIF: Pumilio {165-200}
Pumilio {201-236}
Pumilio {237-273}
HA-8 {289-297}
Pumilio {350-385}
Pumilio {386-422}
Pumilio {424-460}
Database Correlations
UniProt Q15397
Pfam PF08144
References
UniProt :accession Q15397