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pulmonary surfactant-associated protein D; PSP-D; SP-D; collectin-7; lung surfactant protein D (SFTPD, COLEC7, PSPD, SFTP4)
Function:
- innate immune system collectin [4]
- contributes to the lung's defense against inhaled microorganisms
- may participate in the extracellular reorganization or turnover of pulmonary surfactant
- binds strongly maltose residues & to a lesser extent other alpha-glucosyl moieties
- hydroxylation on Pro within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates (putative)
- interacts with DMBT1 & hemagglutinin of influenza A virus [4]
Structure:
- the N-terminus is blocked
- oligomeric complex of 4 set of homotrimers
- belongs to the SFTPD family
- contains 1 C-type lectin domain
- contains 1 collagen-like domain
Compartment:
- secreted, extracellular space, extracellular matrix, surface film
Laboratory:
- surfactant pulmonary-associated protein D in serum
General
glycoprotein
proteolipid
secreted protein
Properties
SIZE: entity length = 375 aa
MW = 38 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
Collagen-like {46-222}
MOTIF: N-glycosylation site {N90}
coiled coil {223-252}
C-type lectin {260-375}
MOTIF: cysteine residue {C281}
MODIFICATION: cysteine residue {C373}
cysteine residue {C351}
MODIFICATION: cysteine residue {C365}
cysteine residue {C365}
MODIFICATION: cysteine residue {C351}
cysteine residue {C373}
MODIFICATION: cysteine residue {C281}
Database Correlations
OMIM 178635
UniProt P35247
PFAM correlations
Entrez Gene 6441
Kegg hsa:6441
References
- UniProt :accession P35247
- SeattleSNPs
http://pga.gs.washington.edu/data/sftpd/
- Functional glycomics gateway - glycan binding
Note: Pulmonary surfactant protein SP-D
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_228
- Wikipedia: Surfactant protein D
https://en.wikipedia.org/wiki/Surfactant_protein_D