Search
pulmonary surfactant-associated protein A2 (SP-A2, SP-A, PSP-A, PSPA, alveolar proteinosis protein, 35 kD pulmonary surfactant-associated protein, SFTPA2, PSAP, SFTP1, SFTPA)
Function:
1) binds to surfactant phospholipids in presence of Ca+2 & contributes to lower the surface tension at the air-liquid interface in the alveoli of the lung
2) essential for normal respiration
Structure:
- oligomeric complex of 6 set of homotrimers
- contains 1 C-type lectin domain.
- contains 1 collagen-like domain
Compartment: secreted
Related
pulmonary surfactant-associated protein A1; PSP-A; PSPA; SP-A; SP-A1; 35 kD pulmonary surfactant-associated protein; Alveolar proteinosis protein; collectin-4 (SFTPA1, COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B)
General
glycoprotein
secreted protein
Properties
SIZE: MW = 26 kD
entity length = 248 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
cysteine residue {C26}
MODIFICATION: cysteine residue {C-INTERCHAIN}
Collagen-like {28-100}
C-type lectin {132-248}
MOTIF: cysteine residue {C155}
MODIFICATION: cysteine residue {C246}
N-glycosylation site {N207}
cysteine residue {C224}
MODIFICATION: cysteine residue {C238}
cysteine residue {C238}
MODIFICATION: cysteine residue {C224}
cysteine residue {C246}
MODIFICATION: cysteine residue {C155}
Database Correlations
OMIM 178642
UniProt Q8IWL1
PFAM correlations
References
UniProt :accession Q8IWL1