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pulmonary foreign body granulomatosis
Etiology:
- injection or nasal inhalation of pulverized tablets, often opioids or stimulants, that contain inert fillers such as crospovidone, talc, or cellulose
Pathology:
- perivascular aggregates of histiocytes & foreign-body giant cells with abundant basophilic foreign material in coral-like structures (histopathology) [1]
- mucicarmine staining
Special laboratory:
- lung-biopsy sample obtained by video-assisted thoracoscopic wedge resection (case report) [1]
Radiology:
- CT of chest (image) [1]
- diffuse, centrilobular nodules in both lungs
Management:
- treatment of the underlying substance abuse disorder
General
granulomatosis
References
- Staloch DA, Hedley JS
Pulmonary Foreign-Body Granulomatosis.
N Engl J Med 2017; 377:1273. September 28, 2017
PMID: 28953434
http://www.nejm.org/doi/full/10.1056/NEJMicm1701787