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pituitary tumor-transforming gene 1 protein-interacting protein; pituitary tumor-transforming gene protein-binding factor; PTTG-binding factor; PBF (PTTG1IP, C21orf1, C21orf3)
Function:
- may facilitate PTTG1 nuclear translocation
- interacts with PTTG1
Structure: contains 1 PSI domain
Compartment:
- membrane; single-pass type 1 membrane protein (putative)
- cytoplasm; nucleus
- found in the cytoplasm & the nucleus [3]
Expression:
- ubiquitous
- induced by transcription factor RUNX2
General
glycoprotein
membrane protein
phosphoprotein
Properties
SIZE: entity length = 180 aa
MW = 20 kD
COMPARTMENT: cytoplasm
cell nucleus
cellular membrane
MOTIF: signal sequence {1-32}
PSI {39-92}
MOTIF: N-glycosylation site {N45}
N-glycosylation site {N54}
transmembrane domain {97-117}
coiled coil {130-165}
MOTIF: Tyr phosphorylation site {Y165}
Tyr phosphorylation site {Y174}
Database Correlations
OMIM 603784
UniProt P53801
Entrez Gene 754
Kegg hsa:754
References
- UniProt :accession P53801
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/PTTG1IPID41944ch21q22.html
- Chien W, Pei L.
A novel binding factor facilitates nuclear translocation and
transcriptional activation function of the pituitary tumor-
transforming gene product.
J Biol Chem. 2000 Jun 23;275(25):19422-7.
PMID: 10781616