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parathyroid hormone 2 receptor; PTH2 receptor (PTH2R PTHR2)
Function:
- specific receptor for parathyroid hormone
- activity is mediated by Gs proteins which activate adenylyl cyclase
- may play a significant role in pancreatic function
- PTH2R presence in neurons suggests it may function as a neurotransmitter receptor
- binds to TIPF39/TIP39
Structure: belongs to the G-protein coupled receptor 2 family
Compartment: cell membrane
Expression:
- expressed abundantly in brain & pancreas
- also expressed in the testis
Related
parathyroid hormone receptors (PTH receptors)
parathyroid hormone; parathormone; parathyrin (PTH)
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 550 aa
MW = 62 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-24}
exoplasmic domain {27-145}
MOTIF: N-glycosylation site {N51}
N-glycosylation site {N106}
N-glycosylation site {N116}
N-glycosylation site {N121}
transmembrane domain {146-169}
cytoplasmic loop {170-176}
transmembrane domain {177-196}
exoplasmic loop {197-237}
transmembrane domain {238-260}
cytoplasmic loop {261-275}
transmembrane domain {276-297}
exoplasmic loop {298-316}
transmembrane domain {317-337}
cytoplasmic loop {338-364}
transmembrane domain {365-383}
exoplasmic loop {384-394}
transmembrane domain {395-417}
cytoplasmic domain {418-550}
Database Correlations
OMIM 601469
UniProt P49190
PFAM correlations
Kegg hsa:5746
References
- UniProt :accession P49190
- Akiko Iida-Klein, Helen Hayes Regional Bone Center,
Columbia University, New York, in: GRECC seminar, Los Angeles CA
12/5/03