psychosine receptor (G protein-coupled receptor 65, GPR65, T cell-death associated protein 8, TDAG8)

Function: - receptor for the glycosphingolipid psychosine (PSY) & several related glycosphingolipids - may play role in activation-induced cell death or in differentiation of T-cells Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta & peripheral blood leukocytes

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: MW = 39 kD entity length = 337 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-15} MOTIF: N-glycosylation site {N2} transmembrane domain {16-36} cytoplasmic loop {37-50} transmembrane domain {51-71} exoplasmic loop {72-89} MOTIF: N-glycosylation site {N79} cysteine residue {C87} MODIFICATION: cysteine residue {C170} transmembrane domain {90-110} cytoplasmic loop {111-129} transmembrane domain {130-150} exoplasmic loop {151-180} MOTIF: N-glycosylation site {N166} cysteine residue {C170} MODIFICATION: cysteine residue {C87} transmembrane domain {181-201} cytoplasmic loop {202-227} transmembrane domain {228-248} exoplasmic loop {249-273} transmembrane domain {274-294} cytoplasmic domain {295-337}

Database Correlations

OMIM 604620 UniProt Q8IYL9 Pfam PF00001 Entrez Gene 8477 Kegg hsa:8477

References

UniProt :accession Q8IYL9