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pseudo-porphyria cutanea tarda (PCT)
A distinct syndrome with blisters & erosions indistinguishable from porphyria cutanea tarda (PCT).
Etiology:
1) drugs: naproxen, ibuprofen, tetracyclines, nalidixic acid, dapsone, amiodarone, bumetanide, furosemide, cyclosporine, etretinate, chlorthalidone, diazide, pyridoxine, oxaprozin, voriconazole, 5-fluorouracil
2) chronic renal failure with hemodialysis
3) tanning salon radiation (visible & UV-A)
4) associated disorders
a) hepatoma
b) lupus erythematosus
c) sarcoidosis
d) Sjogren's syndrome
e) hepatitis C
Pathology:
1) subepidermal bullae
2) little or no dermal inflammation
Clinical manifestations:
1) vesicles & tense bullae on normal-appearing skin
a) painful erosions from easily traumatized bullae
b) atrophic scars at sites of erosions
c) distribution: dorsa of hands & feet, nose
2) fragile skin
Related
porphyria cutanea tarda (PCT)
General
skin disease (dermatologic disorder, dermatopathy, dermatosis)
References
- Color Atlas & Synopsis of Clinical Dermatology, Common
& Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY,
1997, pg 256
- Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 179
- Medical Knowledge Self Assessment Program (MKSAP) 17,
American College of Physicians, Philadelphia 2015