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pseudomelanosis duodeni
Etiology:
- may be associated with
- certain medications (iron supplements & some cardiovascular medications)
- chronic medical conditions (chronic kidney disease)
Epidemiology:
- rare incidental finding
Pathology:
- benign condition
- duodenal mucosa with speckled black pigmentation extending along the villi
- duodenal-biopsy samples stained with hematoxylin & eosin shows macrophages laden with black pigment in the lamina propria
Special laboratory:
- upper GI endoscopy
Complications:
- no known clinical sequelae
Management:
- no specific treatment is indicated
General
pigmentation disorder
intestinal disease
References
- Cook D, Napthali K.
Images in Clinical Medicine: Pseudomelanosis Duodeni.
N Engl J Med 2020; 383:e113. Nov 12
PMID: 33176088
https://www.nejm.org/doi/full/10.1056/NEJMicm2001352