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PR domain zinc finger protein 9; histone-lysine N-methyltransferase PRDM9; PR domain-containing protein 9 (PRDM9, PFM6)
Function:
- histone methyltransferase
- specifically trimethylates Lys-4 of histone H3 during meiotic prophase & is essential for proper meiotic progression
- does not have the ability to mono- & dimethylate Lys-4 of histone H3
- H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation
- role in transcriptional activation of genes during early meiotic prophase
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]
Structure:
- contains 14 C2H2-type Zn+2 fingers
- contains 1 KRAB-related domain
- contains 1 SET domain
Compartment:
- nucleus (putative)
- chromosome
General
C2H2 type zinc finger protein
histone N-methyltransferase
Properties
SIZE: entity length = 894 aa
MW = 103 kD
COMPARTMENT: cell nucleus
MOTIF: Krueppel-associated box
NAME: Krueppel-associated box
SITE: 23-86
MOTIF: KRAB A box
KRAB B box
EFFECTOR-BOUND: Zn+2
SET domain {246-362}
Zn finger C2H2-type
SITE: 388-411
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 524-546
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 552-574
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 580-602
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 608-630
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 636-658
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 664-686
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 692-714
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 720-742
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 748-770
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 776-798
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 804-826
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 832-854
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 860-882
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 609760
UniProt Q9NQV7
PFAM correlations
Entrez Gene 56979
Kegg hsa:56979
ENZYME 2.1.1.43
References
UniProt :accession Q9NQV7