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PR domain zinc finger protein 7; histone-lysine N-methyltransferase PRDM7; PR domain-containing protein 7 (PRDM7, PFM4)
Function:
- histone methyltransferase (putative)
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]
Structure:
- contains 1 KRAB-related domain
- contains 1 SET domain
Compartment:
- nucleus (putative)
- chromosome
Alternative splicing:
- named isoforms=3
- at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Comparative biology:
- the mouse orthologous protein seems not to exist according to [2]
- human PRDM7 & PRDM9 genes, a pair of close paralogs corresponding to a single mouse gene Prdm9, were generated by a recent gene duplication event after the divergence of the ancestors of human & mouse
General
histone N-methyltransferase
zinc finger protein
Properties
SIZE: entity length = 492 aa
MW = 56 kD
COMPARTMENT: cell nucleus
MOTIF: Krueppel-associated box
NAME: Krueppel-associated box
SITE: 23-86
MOTIF: KRAB A box
KRAB B box
EFFECTOR-BOUND: Zn+2
SET domain {246-362}
Database Correlations
OMIM 609759
UniProt Q9NQW5
PFAM correlations
Entrez Gene 11105
Kegg hsa:11105
ENZYME 2.1.1.43
References
- UniProt :accession Q9NQW5
- Fumasoni I et al
Family expansion and gene rearrangements contributed to the
functional specialization of PRDM genes in vertebrates.
BMC Evol Biol. 2007 Oct 4;7:187.
PMID: 17916234