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PR domain zinc finger protein 6; histone-lysine N-methyltransferase PRDM6; PR domain-containing protein 6 (PRDM6, PFM3)
Function:
- putative histone methyltransferase
- acts as a transcriptional repressor of smooth muscle gene expression
- promotes transition from differentiated to proliferative smooth muscle by suppressing differentiation & maintaining the proliferative potential of vascular smooth muscle cells
- also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival & differentiation
- unclear whether it has histone methyltransferase activity in vivo
- according to some authors, it does not act as a histone methyltransferase by itself & represses transcription by recruiting EHMT2/G9a
- according to others, it possesses histone methyltransferase activity when associated with other proteins & specifically methylates Lys-20 of histone H4 in vitro
- Lys-20 methylation represents a specific tag for epigenetic transcriptional repression (putative)
- interacts with HDAC1, HDAC2, HDAC3, CBX1 & EP300
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]
Structure:
- contains 4 C2H2-type Zn+2 fingers
- contains 1 SET domain
Compartment: nucleus (putative)
Alternative splicing: named isoforms=3
General
C2H2 type zinc finger protein
histone N-methyltransferase
Properties
SIZE: entity length = 595 aa
MW = 64 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 47-73
MOTIF: proline residue (SEVERAL)
alanine-rich region {97-106}
MOTIF: alanine residue (SEVERAL)
alanine-rich region {123-129}
MOTIF: alanine residue (SEVERAL)
glycine-rich region {151-162}
alanine-rich region {228-232}
MOTIF: alanine residue (SEVERAL)
SET domain {247-369}
Zn finger C2H2-type
SITE: 473-495
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 501-523
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 529-551
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 557-579
EFFECTOR-BOUND: Zn+2
Database Correlations
UniProt Q9NQX0
PFAM correlations
Entrez Gene 93166
Kegg hsa:93166
ENZYME 2.1.1.43
References
UniProt :accession Q9NQX0