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PR domain zinc finger protein 5; PR domain-containing protein 5 (PRDM5, PFM2)
Function:
- sequence-specific DNA-binding transcription factor
- represses transcription at least in part by recruitment of histone methyltransferase EHMT2/G9A & histone deacetylases such as HDAC1
- regulates hematopoiesis-associated protein-coding & microRNA (miRNA) genes
- may regulate the expression of proteins involved in extracellular matrix development & maintenance, including fibrillar collagens, such as COL4A1 & COL11A1, connective tissue components, such as HAPLN1, & molecules regulating cell migration & adhesion, including EDIL3 & TGFB2
- may cause G2/M arrest & apoptosis in cancer cells
- interacts with EHMT2/G9A, GFI1 & HDAC1
Structure:
- contains 16 C2H2-type Zn+2 fingers
- contains 1 SET domain
Compartment: nucleus
Alternative splicing: named isoforms=3
Expression:
- widely expressed
- highest levels in colon & ovary
- tends to be silenced in breast, colorectal, gastric & liver cancer tissues
Pathology:
- defects in PRDM5 are the cause of brittle cornea syndrome type 2
General
C2H2 type zinc finger protein
DNA-binding protein
Properties
SIZE: entity length = 630 aa
MW = 73 kD
COMPARTMENT: cell nucleus
MOTIF: SET domain {8-128}
Zn finger C2H2-type
SITE: 167-190
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 199-221
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 234-256
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 262-287
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 295-317
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 320-342
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 348-370
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 376-398
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 404-426
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 432-455
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 461-483
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 489-511
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 517-539
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 545-567
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 573-595
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 602-625
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM correlations
UniProt Q9NQX1
PFAM correlations
Entrez Gene 11107
Kegg hsa:11107
References
UniProt :accession Q9NQX1