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PR domain zinc finger protein 2; GATA-3-binding protein G3B; lysine N-methyltransferase 8; MTB-ZF; MTE-binding protein; PR domain-containing protein 2; retinoblastoma protein-interacting zinc finger protein; zinc finger protein RIZ (PRDM2, KMT8, RIZ)

Function: - S-adenosyl-L-methionine-dependent histone methyltransferase - specifically methylates Lys-9 of histone H3 - may function as a DNA-binding transcription factor - binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene & may act as a transcriptional activator of this gene - binds to the retinoblastoma protein (RB) - interacts withGATA3 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone] Structure: - contains 8 C2H2-type Zn+2 fingers - contains 1 SET domain Compartment: nucleus Alternative splicing: Alternative initiation: - named isoforms=3 - alternative initiation at Met-202 of isoform 1 Expression: - highly expressed in retinoblastoma cell lines & in brain tumors - also expressed in a number of other cell lines & in brain, heart, skeletal muscle, liver & spleen - isoform 1 is expressed in testis at much higher level than isoform 3

General

C2H2 type zinc finger protein histone N-methyltransferase nuclear protein phosphoprotein

Properties

SIZE: entity length = 1718 aa MW = 189 kD COMPARTMENT: cell nucleus MOTIF: SET domain {27-145} acidic region {268-296} MOTIF: acidic residue (SEVERAL) Retinoblastoma protein binding {294-316} Zn finger C2H2-type SITE: 360-382 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 390-412 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 483-506 EFFECTOR-BOUND: Zn+2 Thr phosphorylation site {T641} Ser phosphorylation site {S643} Ser phosphorylation site {S739} Ser phosphorylation site {S743} proline-rich region SITE: 933-1049 MOTIF: proline residue (SEVERAL) SH3-binding site NAME: SH3-binding site SITE: 970-979 SH3-binding site NAME: SH3-binding site SITE: 985-998 SH3-binding site NAME: SH3-binding site SITE: 1028-1052 serine-rich region {1052-1074} MOTIF: serine residue (SEVERAL) Zn finger C2H2-type SITE: 1134-1156 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1162-1185 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1191-1214 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1333-1355 EFFECTOR-BOUND: Zn+2 lysine-rich region {1361-1447} MOTIF: lysine residue (SEVERAL) Zn finger C2H2-type SITE: 1455-1478 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 601196 UniProt Q13029 PFAM correlations Entrez Gene 7799 Kegg hsa:7799 ENZYME 2.1.1.43

References

  1. UniProt :accession Q13029
  2. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/PRDM2ID41834ch1p36.html