protocol for oral desensitization to beta lactam antibiotics

Procedure: time (min) dose (mg) cumulative dose (mg) 0 0.05 0.05 15 0.1 0.15 30 0.2 0.35 45 0.4 0.35 60 0.8 0.75 75 1.6 1.55 90 3.2 3.15 105 6.0 6.35 120 12.0 24.35 135 24.0 48.35 150 50.0 98.35 165 100.0 198.35 180 200.0 398.35 195 400.0 798.35 After completion, observe patient for 15 minutes. If no problems, administer 1 g of same agent intravenously. The drug suspension 0.5-50 mg/mL is diluted in 30 mL of water for ingestion.

General

clinical procedure protocol

References

Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998