protocadherin-21; cadherin-related family member 1; photoreceptor cadherin; prCAD (CDHR1, KIAA1775, PCDH21, PRCAD)

Function: - potential Ca⁺²-dependent cell-adhesion protein - may be required for the structural integrity of the outer segment of photoreceptor cells - undergoes proteolytic cleavage; produces a soluble 95 kD N-terminal fragment & a 25 kD cell-associated C-terminal fragment Structure: contains 6 cadherin domains Compartment: - membrane (putative) - localized at the junction between the inner & outer segments of rod & cone photoreceptors cells - confined to the base of the outer segment - localized on the edges of nascent evaginating disks on the side of the outer segment opposite the connecting cilium - colocalized with rhodopsin between postnatal days 2 & 9 at the base of the growing outer segment region Alternative splicing: named isoforms=2 Expression: - expressed at postnatal day 2 at the apical tip of the rod photoreceptor cells, the site of the developing outer segment

General

glycoprotein membrane protein protocadherin (PCDH) receptor

Properties

SIZE: entity length = 859 aa MW = 94 kD COMPARTMENT: plasma membrane MOTIF: signal sequence {1-19} cadherin domain {36-135} MOTIF: N-glycosylation site {N58} N-glycosylation site {N89} cadherin domain {136-246} cadherin domain {247-353} MOTIF: N-glycosylation site {N296} cadherin domain {359-472} cadherin domain {473-576} cadherin domain {573-688} transmembrane domain {701-721} proline-rich region SITE: 773-829 MOTIF: proline residue (SEVERAL)

Database Correlations

OMIM 609502 UniProt Q96JP9 Pfam PF00028 Entrez Gene 92211

References

UniProt :accession Q96JP9