Search
prothrombin antibody in serum/plasma
Indications:
- evaluation* of
- antiphospholipid antibody syndrome
- lupus anticoagulant
- hypercoagulability
* Experimental, not proven clinical utility [1]
Clinical significance:
1) occurs in association with
a) low-grade non-Hodgkin's lymphoma
b) chronic lymphocytic leukemia
2) enhances clearance of factor II (prothrombin) from the circulation
Laboratory:
-> in vitro coagulation tests correct with addition of normal plasma because the autoantibody does not interact with the active site of an enzyme
Related
coagulation factor II inhibitor in plasma
prothrombin; coagulation factor II; contains: activation peptide fragment 1; activation peptide fragment 2; thrombin light chain; thrombin heavy chain (F2)
Specific
prothrombin antibody IgG
prothrombin antibody IgM
General
serology
clinical coagulation test
References
- Aetna
Clinical Policy Bulletin:
Antiprothrombin Antibody Testing
http://www.aetna.com/cpb/medical/data/600_699/0662.html
- Fleck RA et al
Anti-prothrombin antibodies and the lupus anticoagulant
Blood August 1, 1988 vol. 72 no. 2 512-519
http://bloodjournal.hematologylibrary.org/content/72/2/512
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Schiller G, in: UCLA Intensive Course in Geriatric Medicine &
Board Review, Marina Del Ray, CA, Sept 12-15, 2001