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protein Z-dependent protease inhibitor; PZ-dependent protease inhibitor; PZI; Serpin A10; regeneration-associated serpin-1 (SERPINA10, ZPI, UNQ707/PRO1358)
Function:
- inhibits factor Xa in the presence of protein Z, Ca+2 & phospholipid
- phosphorylation sites are present in the extracellularmedium
Structure: belongs to the serpin family
Compartment: secreted Expession:
- synthesized in liver & secreted into plasma.
Related
SERPINA10 gene mutation
General
glycoprotein
secreted protein
serine protease inhibitor; serpin
Properties
SIZE: entity length = 444 aa
MW = 51 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
N-glycosylation site {N36}
Ser phosphorylation site {S56}
Ser phosphorylation site {S61}
N-glycosylation site {N180}
N-glycosylation site {N197}
N-glycosylation site {N295}
peptide motif {408-409}
INHIBITS: serine protease
Database Correlations
OMIM correlations
MORBIDMAP 605271
UniProt Q9UK55
Pfam PF00079
Entrez Gene 51156
Kegg hsa:51156
References
- UniProt :accession Q9UK55
- SeattleSNPs
http://pga.gs.washington.edu/data/serpina10/